Eating low-carb and high-fat diet can help you fight against Alzheimer's disease, by protecting neurons from death during the progression of Alzheimer's disease, according to new research in mice.
"Ketogenic" is a term for a low-carb diet (like the Atkins diet). The idea is for you to get more calories from protein and fat and less from carbohydrates. You cut back most on the carbs that are easy to digest, like sugar, soda, pastries and white bread.
Early in the development of Alzheimer's disease, the brain becomes overexcited, potentially through the loss of inhibitory, or GABAergic, interneurons that keep other neurons from signalling too much.
As interneurons require more energy compared to other neurons, they may be more susceptible to dying when they encounter the Alzheimer's disease protein amyloid beta.
Amyloid beta has been shown to damage mitochondria - the metabolic engine for cells - by interfering with SIRT3, a protein that preserves mitochondrial functions and protects neurons.
Researchers from the Society for Neuroscience genetically reduced levels of SIRT3 in mouse models of Alzheimer's disease.
Mice with low levels of SIRT3 experienced a much higher mortality rate, more violent seizures and increased interneuron death compared to the mice from the standard Alzheimer's disease model and control mice.
However, the mice with reduced levels of SIRT3 experienced fewer seizures and were less likely to die when they ate a diet rich in ketones, a specific type of fatty acid.
The diet also increased levels of SIRT3 in the mice.
"Increasing SIRT3 levels via ketone consumption may be a way to protect interneurons and delay the progression of Alzheimer's disease," the report stated.
First Published: Dec 10, 2019 4:50 PM IST
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