homehealthcare NewsCOVID 19 new variant Pirola could be highly immune evasive: Japanese study

COVID-19 new variant Pirola could be highly immune evasive: Japanese study

The study on ‘Pirola’, titled ‘Transmissibility, infectivity, and immune evasion of the SARS-CoV-2 BA.2.86 variant’, has been recently published in The Lancet’s journal.

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By CNBCTV18.com Oct 27, 2023 6:47:26 PM IST (Published)

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COVID-19 new variant Pirola could be highly immune evasive: Japanese study
In a recent study, a team of Japanese researchers discovered that the new variant of COVID-19, named ‘Pirola’ or BA.2.86, could be one of the ‘highly immune evasive’ among all other variants of the virus found so far. The study on ‘Pirola’, titled ‘Transmissibility, infectivity, and immune evasion of the SARS-CoV-2 BA.2.86 variant’, has been recently published in the November edition of The Lancet’s Journal.

Reportedly, the Pirola variant was found in India in late August this year. However, it could not create any noticeable surge in cases in the country. Similar to India, there were several other countries in Europe, North America, and Africa reported to have fewer cases of the Pirola variant. Following the reporting of cases, the World Health Organization (WHO) started monitoring the variant.
While studying the newly found strain, an analysis was carried out by a team of scientists in Sato Lab, Tokyo, Japan, to examine the behaviour of the variant. According to the study, the results established that the blood samples taken from the people who have been vaccinated with extra doses or different types of vaccines did not respond any better against the Pirola or BA.2.86. Later, when the team used the antibodies that worked on the other strains, it also did not result in any positive effects on the new variant.
“The sera obtained from individuals vaccinated with third-dose monovalent, fourth-dose monovalent, BA.1 bivalent, and BA.5 bivalent mRNA vaccines exhibited very little or no antiviral effects against BA.2.86. Additionally, the three monoclonal antibodies which worked against the parental BA.2 did not exhibit antiviral effects against BA.2.86,” mentioned the study.
“Finally, a neutralisation assay using XBB breakthrough infection sera showed that the 50% neutralisation titre of XBB breakthrough infection sera against BA.2.86 was significantly lower than that against EG.5.1. Altogether, these results suggest that BA.2.86 is one of the most highly immune evasive variants so far,” it further added.
Meanwhile, the SARS-CoV-2 XBB descendants such as XBB.1.5 and EG.5.1 were the predominant variants that circulated across the world. However, a lineage which is distinct from the XBB was identified and named BA.2.86 on August 14, 2023.
The study states that the newly established variant ‘Pirola’ has more than 30 mutations in the spike protein when it is compared to the XBB and the parental BA.2, and many of these mutations are assumed to be associated with immune evasion as well.

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